化工学院教师介绍：郑科

►个人简介

工作职位：药物制剂教研室 讲师, 硕士生导师

办公地址：771771威尼斯cm大全 精细化工楼 212-1

工作邮箱：zhengke_qust@163.com

研究生招生：100702药剂学

2009年于天津医科大学获得药学学士学位，2015年博士毕业于福州大学，先后在天津药物研究院、中科院福建物质结构研究所进行科研工作，2016年就职于771771威尼斯cm大全，主要从事新制剂、光动力药物和抗肿瘤药物等领域的研究工作，发表SCI论文10余篇，参与多项国家自然科学基金山东省基金项目。

►论文、专著与专利

1、主要论文

[1] Dual actions of albumin packaging and tumor targeting enhance the antitumor efficacy and reduce the cardiotoxicity of doxorubicin in vivo. International journal of nanomedicine, 2015, 10: 5327.

[2] A novel drug carrier targeting uPAR for tumor imaging and treatment, First Sino-German Symposium on “Singlet molecular oxygen and photodynamic effects”. Photonics & Lasers in Medicine, 2015.

[3] Novel pH-Triggered Doxorubicin-Releasing Nanoparticles Self-Assembled by Functionalized β-Cyclodextrin and Amphiphilic Phthalocyanine for Anticancer Therapy. ACS Applied Materials & Interfaces. 2021;13(9):10674–10688. doi:10.1021/acsami.0c19027.

[4] Multifunctional photo-responsive liposomes for tumor imaging and phototherapy to enhance the antitumor efficacy and reduce the hepatotoxicity of methotrexate. Dyes and Pigments. 2021;196:109790-109800.

[5] Tumor Targeting Chemo- and Photodynamic Therapy Packaged in Albumin for Enhanced Anti-Tumor Efficacy. International Journal of Nanomedicine. 2020;15:151-167.

[6] Enhanced Antitumor Efficacy and Imaging Application of Photosensitizer-Formulated Paclitaxel. ACS Applied Materials & Interfaces. 2020;12(4):4221-4230.

[7] Nanoparticle Binding to Urokinase Receptor on Cancer Cell Surface Triggers Nanoparticle Disintegration and Cargo Release. Theranostics. 2019;9(3):884-899.

[8] Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment. International Journal of Nanomedicine. 2018;19(13):7681-7695.

[9] Be Active or Not: the Relative Contribution of Active and Passive Tumor Targeting of Nanomaterials. Nanotheranostics. 2017;1(4):346-357.

[10] Rapid killing of bacteria by a new type of photosensitizer. Applied Microbiology and Biotechnology. 2017;101(11):4691-4700. doi: 10.1007/s00253-017-8133-8.

[11] A drug carrier targeting murine uPAR for photodynamic therapy and tumor imaging. Acta Biomaterialia. 2015;23:116-126.

[12] Photo-triggered Release of Doxorubicin from Liposomes Formulated by Amphiphilic Phthalocyanines for Combination Therapy to Enhance Antitumor Efficacy. Journal of Materials Chemistry B. 2020;8:8022-8036.

[13] Zhou X, Zheng K, Li R, et al. A drug carrier targeting murine uPAR for photodynamic therapy and tumor imaging. Acta biomaterialia, 2015, 23: 116-126.

[14] Zhang F L, Huang Q, Zheng K, et al. A novel strategy for targeting photodynamic therapy. Molecular combo of photodynamic agent zinc (II) phthalocyanine and small molecule target-based anticancer drug erlotinib. Chemical Communications, 2013, 49(83): 9570-9572.

►承担的科研项目

[1]   国家自然科学基金面上项目，21471033，生物素介导靶向光动力治疗-化疗联用抗癌药物的合成及构效关系研究，参加

[2]  国家自然科学基金青年基金，21101028，叶酸-酞菁共轭物抗癌光敏剂的合成及其靶向光动力活性研究，参加

[3] 国家自然科学基金面上项目, 81770895，鼻腔粘膜-三叉神经节-角膜神经通路在药物防治糖尿病性角膜病变中的作用及其机制研究，参加