化工学院教师介绍：郭传龙

►个人简介

工作职位：化工学院药物化学教研室，副教授，硕士生导师

办公地址：771771威尼斯cm大全 CCF1021/1023（青岛市市北区郑州路53号）

招生专业：药学1007/1055

联系方式：gcl_cpu@126.com；guochuanlong@qust.edu.cn

2019年获中国科学院海洋研究所海洋生物学专业博士学位，主要从事新型抗肿瘤药物研制与开发、活性化合物筛选及新型药物递送系统构建及应用。作为项目负责人，主持国家自然科学基金1项，山东省自然科学基金2项，参与国家自然科学基金项目3项。近五年，其中第一或通讯作者在J Med Chem，Eur J Med Chem等期刊发表SCI论文20余篇。

►代表性论文（通讯或第一作者）

[1] Gao, Xintao et al. Regulation of Eukaryotic Translation Initiation Factor 4E as a Potential Anticancer Strategy. J Med Chem, 2023. （一区，通讯作者）

[2] Zhang, Qin et al. Design, synthesis and SAR of novel 7-azaindole derivatives as potential Erk5 kinase inhibitor with anticancer activity. Bioorg Med Chem, 2023. （二区，通讯作者）

[3] Gao, Xintao et al. Fucoidan-proanthocyanidins nanoparticles protect against cisplatin-induced acute kidney injury by activating mitophagy and inhibiting mtDNA-cGAS/STING signaling pathway. Int J Biol Macromol, 2023. （一区，通讯作者）

[4] Liu, Shuai et al. Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway. Food Chem Toxicol, 2023 （一区，通讯作者）

[5] Qi, Xueju et al. EGPI-1, a novel eIF4E/eIF4G interaction inhibitor, inhibits lung cancer cell growth and angiogenesis through Ras/MNK/ERK/eIF4E signaling pathway. Chem Biol Interact, 2022 （二区，通讯作者）

[6] Gao, Xintao et al. Fucoidan-ferulic acid nanoparticles alleviate cisplatin-induced acute kidney injury by inhibiting the cGAS-STING pathway. Int J Biol Macromol, 2022.（一区，通讯作者）

[7] Wu, Xiaochen et al. Novel poly (ADP-ribose) polymerases inhibitor DHC-1 exhibits in vitro and in vivo anticancer activity on BRCA-deficient pancreatic cancer cells. Food Chem Toxicol, 2021 （一区，通讯作者）

[8] Guo, Chuanlong et al. The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549 cell death in vitro and in vivo. Food Chem Toxicol, 2020（一区，第一作者）

[9] Guo, Chuanlong et al. BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo. Int J Biol Macromol, 2020（一区，第一作者）

[10] Wang, Jun et al. Novel eIF4E/eIF4G protein-protein interaction inhibitors DDH-1 exhibits anti-cancer activity in vivo and in vitro. Int J Biol Macromol, 2020（一区，通讯作者）

[11] Guo, Chuanlong et al. Discovery of Novel Bromophenol-Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer. J Med Chem, 2019（一区，第一作者）

[12] Wang, Lijun et al. Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment. Eur J Med Chem, 2019（一区，第一作者）

►承担的主要科研项目

[1] 2024.1-2026.12国家自然科学基金青年基金，主持，在研

[2] 2021.1-2023.12山东省自然科学基金青年基金，主持，在研。

[3] 2019.9-2024.8771771威尼斯cm大全人才启动经费。主持，在研。

[4] 2023.1-2024.12中国科学院暨山东省实验海洋生物学重点实验室开放课题。主持，在研。

[5] 2015.7-2016.12山东省自然科学基金， ZR2015PH06。主持，已结题。